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Phone: 301-655-1084 Email: info@glycorx.com

Novel Therapeutics:

Our proprietary approach is groundbreaking. We leverage carbohydrate functionality which makes our biologic glycoprotein drugs First-in-Class. The drug target is Galectin-3 (a beta-galactoside-binding lectin), known to be involved in many diseases that are associated with chronic inflammation such as cancer, organ fibrosis, and type 2 diabetes.

Our Novel Products Break Galectin-3’s Natural Affinity:

The interactions of Galectin-3 and its endogenous ligands are typically strong – in the nanomolar range. So, it’s important to break the Galectin-3’s natural interactions for the development of a successful Galectin-3 targeted therapy. Our high affinity Galectin-3 antagonists (GM100 series, patent awarded) are more powerful than its natural ligands as they bind Galectin-3 with picomolar afiinity. As such, our drug candidates act as decoys in the treatment of cancers and metabolic diseases.

Our GM100 series drugs are:

  • Exceptionally potent with picomolar affinity (100X stronger than a typical antibody). Our products are unique as they outcompete Galectin-3’s natural affinity to its endogenous ligands.
  • No off-target effects observed in animal models
  • Non-immunogenic.
  • Favorable pharmacokinetics
  • High therapeutic index
  • Consistent preparation of recombinant glycoprotein
  • Scalable

Our current indications for the GM100 series drugs are:

  • Drug resistant mCRPC (metastatic castration-resistant prostate cancer)
  • NASH (Non-alcoholic steatohepatitis)
  • Type 2 diabetes

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